Nitric Oxide: Oxygen Radical Interactions in Atherosclerosis
نویسندگان
چکیده
منابع مشابه
Nitric oxide function in atherosclerosis
Atherosclerosis is a chronic inflammatory process in the intima of conduit arteries, which disturbs the endothelium-dependent regulation of the vascular tone by the labile liposoluble radical nitric oxide (NO) formed by the constitutive endothelial nitric oxide synthase (eNOS). This defect predisposes to coronary vasospasm and cardiac ischaemia, with anginal pain as the typical clinical manifes...
متن کاملAtherosclerosis and nitric oxide production.
To the Editor: We read with interest 2 recent reports published in Circulation. We believe that the work of Qian et al1 and Ridker et al2 has an important connection in light of our recent findings.3 Qian and coworkers1 showed that in cholesterol-fed rabbits, increased nitric oxide production, via nitric oxide synthase gene transfer, produced rapid amelioration of several markers of atheroscler...
متن کاملReview Article. Nitric oxide synthesis in atherosclerosis
In 1980 Furchgott and Zawadzki discovered that acetylcholine-induced relaxation of rabbit aortic strips required an intact endothelium. They found that stimulation of muscarinic receptors on the endothelium led to the release of a non-prostanoid relaxing factor which they named endothelium-derived relaxing factor. Further studies have established the importance of endothelium-derived relaxing f...
متن کاملNitric oxide and oxygen metabolism.
Introduction Inhibition of mitochondrial respiration has been associated with the cytotoxicity of NO right from the beginning of NO research [1,2]. Recent findings have confirmed the importance of mitochondrial inhibition, but put the previous research into a new context. Here we review our findings that: (a) NO reversibly inhibits O2 consumption by isolated cytochrome oxidase, mitochondria, ne...
متن کاملInteractions between nitric oxide, oxygen, reactive oxygen species and reactive nitrogen species.
ROS (reactive oxygen species) and RNS (reactive nitrogen species) are central to the innate immunity that protects us from infection, but also contribute to degenerative diseases and possibly aging. However, ROS and RNS are increasingly recognized to contribute to physiological signalling. This review briefly describes the main interactions between ROS and RNS and shows how their origins, chemi...
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ژورنال
عنوان ژورنال: Biological Research
سال: 2000
ISSN: 0716-9760
DOI: 10.4067/s0716-97602000000200017